期刊
GLAND SURGERY
卷 9, 期 -, 页码 S47-S53出版社
AME PUBLISHING COMPANY
DOI: 10.21037/gs.2019.12.24
关键词
Noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP); thyroid cytology; indeterminate nodules; molecular markers
类别
Since its first official definition in 2016, the new histo-pathological entity of noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) has attracted much interest among thyroidologists worldwide. This is a subset of encapsulated and noninvasive follicular variant papillary thyroid cancer, whose introduction had the intent of de-escalating treatment given its very low malignant potential, approaching to that of follicular adenomas. Many researchers focused on the possibility of preoperatively identifying NIFTP, and investigated their cyto-morphological and molecular characteristics; other ones explored histological and clinical-pathological NIFTP features. Although the majority of published studies confirmed that NIFTP are indolent lesions, some papers did question their low-risk nature. In this brief review, the main aspects of histology, cytology and molecular pathology of NIFTP are discussed based on the current literature.
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