期刊
DIAGNOSTICS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics10020115
关键词
rhabdomyosarcoma; pediatric soft tissue sarcomas; plasmatic biomarkers; diagnostic and prognostic factors; tumor-associated antigens; tumor-associated autoantibodies; metastatic tumors; IGFBP2
资金
- Fondazione Associazione Italiana per la Ricerca sul Cancro (AIRC) PI [15813]
- Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO) [17/09]
- Associazione Italiana contro le Leucemie-Linfomi e Mieloma ONLUS (AIL)
Insulin-like growth factor-binding protein 2 (IGFBP2) is a tumor-associated protein measurable in patients' biopsies and blood samples. Increased IGFBP2 expression correlates with tumor severity in rhabdomyosarcoma (RMS). Thus, we examined the plasmatic IGFBP2 levels in 114 RMS patients and 15 healthy controls by ELISA assay in order to evaluate its value as a plasma biomarker for RMS. Additionally, we looked for the presence of a humoral response against IGBFP2 protein measurable by the production of anti-IGFBP2 autoantibodies. We demonstrated that both circulating IGFBP2 protein and autoantibodies were significantly higher in RMS patients with respect to controls and their combination showed a better discriminative capacity. IGFBP2 protein identified metastatic patients with worse event-free survival, whereas both IGFBP2 and anti-IGFBP2 antibodies negatively correlated with overall survival. Our study suggests that IGFBP2 and anti-IGFBP2 antibodies are useful for diagnostic and prognostic purposes, mainly as independent negative prognostic markers in metastatic patients. This is the first study that reports a specific humoral response in RMS plasma samples and proves the value of blood-based biomarkers in improving risk assessment and outcome of metastatic RMS patients.
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