期刊
PATHOGENS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pathogens9030167
关键词
foot-and-mouth disease; foot-and-mouth disease virus; FMD; FMDV; virus; carrier; persistent infection; transmission; pathogenesis; cattle
类别
资金
- U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS) [1940-32000-061-00D]
- USDA-ARS [58-8064-7-018]
- Kansas State University [58-8064-7-018]
The existence of a prolonged, subclinical phase of foot-and-mouth disease virus (FMDV) infection in cattle was first recognized in the 1950s. Since then, the FMDV carrier state has been a subject of controversy amongst scientists and policymakers. A fundamental conundrum remains in the discordance between the detection of infectious FMDV in carriers and the apparent lack of contagiousness to in-contact animals. Although substantial progress has been made in elucidating the causal mechanisms of persistent FMDV infection, there are still critical knowledge gaps that need to be addressed in order to elucidate, predict, prevent, and model the risks associated with the carrier state. This is further complicated by the occurrence of a distinct form of neoteric subclinical infection, which is indistinguishable from the carrier state in field scenarios, but may have substantially different epidemiological properties. This review summarizes the current state of knowledge of the FMDV carrier state and identifies specific areas of research in need of further attention. Findings from experimental investigations of FMDV pathogenesis are discussed in relation to experience gained from field studies of foot-and-mouth disease.
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