期刊
PATHOGENS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pathogens9020130
关键词
PEDV; lactogenic immunity; IgA antibodies; gut-mammary gland-secretory IgA axis; pregnancy; lymphocyte trafficking
类别
资金
- USDA NADC ARS Grant [60054098]
- AFRI NIFA Fellows Program/U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture [60046830]
- National Institute of Food and Agriculture/USDA Competitive Grants [2015-67015-23067]
- NIH NICHD [R01 HD095881]
Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control challenging. Lactogenic immunity induced via the gut-mammary gland-secretory IgA (sIgA) axis, remains the most promising and effective way to protect suckling piglets from PEDV. Therefore, a successful PEDV vaccine must induce protective maternal IgA antibodies that passively transfer into colostrum and milk. Identifying variables that influence lymphocyte migration and IgA secretion during gestation and lactation is imperative for designing maternal immunization strategies that generate the highest amount of lactogenic immune protection against PEDV in suckling piglets. Because pregnancy-associated immune alterations influence viral pathogenesis and adaptive immune responses in many different species, a better understanding of host immune responses to PEDV in pregnant swine may translate into improved maternal immunization strategies against enteric pathogens for multiple species. In this review, we discuss the role of host factors during pregnancy on antiviral immunity and their implications for generating protective lactogenic immunity in suckling neonates.
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