期刊
ANTIOXIDANTS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox9020124
关键词
cerebrovascular disease; cerebral cavernous malformations; dicarbonyl stress; glyoxalase 1; methylglyoxal; advanced glycation end products; glutathione; S-glutathionylation; oxidative stress
资金
- Telethon Foundation [GGP15219]
- Fondazione CRT
- Universita degli Studi di Torino
Dicarbonyl stress is a dysfunctional state consisting in the abnormal accumulation of reactive alpha-oxaldehydes leading to increased protein modification. In cells, post-translational changes can also occur through S-glutathionylation, a highly conserved oxidative post-translational modification consisting of the formation of a mixed disulfide between glutathione and a protein cysteine residue. This review recapitulates the main findings supporting a role for dicarbonyl stress and S-glutathionylation in the pathogenesis of cerebrovascular diseases, with specific emphasis on cerebral cavernous malformations (CCM), a vascular disease of proven genetic origin that may give rise to various clinical signs and symptoms at any age, including recurrent headaches, seizures, focal neurological deficits, and intracerebral hemorrhage. A possible interplay between dicarbonyl stress and S-glutathionylation in CCM is also discussed.
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