期刊
BIOMOLECULES
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom10010083
关键词
mitochondria; oxidative stress; photodynamic therapy; cancer therapy; antioxidant therapy; cell therapy; drug delivery system; liposomes; MITO-Porter
资金
- Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government (MEXT) [17H02094]
- Project for Translational and Clinical Research Core Centers from Japan Agency for Medical Research and Development (AMED) [A150]
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [17H02094] Funding Source: KAKEN
There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress.
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