期刊
BIOMOLECULES
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom10010066
关键词
hepatocellular carcinoma; long non-coding RNAs; metastasis; epigenetics; transcription
资金
- Natural Science Foundation of Hubei Province [2019CFB591]
- Foundation of Health and Family Planning Commission of Hubei Province [WJ2016-Y-02]
- Central Funds Guiding the Local Science and Technology Development of Hubei Province [2019ZYYD066]
- National Research Foundation of Singapore
Long non-coding RNAs (lncRNAs) play multifaceted roles in modulating gene expression under both physiological and pathological processes. The dysregulation of lncRNAs has been increasingly linked with many human diseases, including a plethora of cancers. Mounting evidence indicates that lncRNAs are aberrantly expressed in hepatocellular carcinoma (HCC) and can regulate HCC progression, as well as metastasis. In this review, we summarize the recent findings on the expanding roles of lncRNAs in modulating various functions of HCC, and elaborate on how can lncRNAs impact HCC metastasis and progression via interacting with chromatin, RNA, and proteins at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the current advances regarding the signaling pathways of lncRNAs in HCC metastasis and sheds light on the possible application of lncRNAs for the prevention and treatment of HCC.
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