期刊
BIOMOLECULES
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biom9120841
关键词
Order Verongiida; Red Sea sponges; Aplysinella species; bromotyrosine-derived metabolites; psammaplysin A; psammaplysin E; psammaplysin Z and 19-hydroxypsammaplysin Z; cytotoxicity; human cancer cell lines
资金
- Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [G-1436-141-251]
As part of our ongoing interest to identify bioactive chemical entities from marine invertebrates, the Red Sea specimen of the Verongid sponge Aplysinella species was studied. Repeated chromatographic fractionation of the methanolic extract of the sponge and HPLC purification of the cytotoxic fractions led to the isolation and the identification of two new compounds, psammaplysin Z and 19-hydroxypsammaplysin Z (1 and 2), together with the previously reported psammaplysins A (3) and E (4). The structural determination of 1-4 was supported by interpretation of their NMR and high-resolution mass spectra. Psammaplysins A and E displayed cytotoxic activity against MBA-MB-231 and HeLa cell lines with IC50 values down to 0.29 mu M. On the other hand, psammaplysin Z and 19-hydroxypsammaplysin Z were moderately cytotoxic, indicating the importance of the terminal amine and 2-(methylene)cyclopent-4-ene-1,3-dione moieties in 3 and 4 for potent cytotoxic activity.
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