期刊
TRANSLATIONAL LUNG CANCER RESEARCH
卷 8, 期 6, 页码 895-+出版社
AME PUBLISHING COMPANY
DOI: 10.21037/tlcr.2019.11.17
关键词
Non-small cell lung cancer (NSCLC); programmed cell death protein-1 (PD-1); programmed cell death protein-ligand 1 (PD-L1); T cell immunoglobulin and mucin-domain containing-3 (TLM-3); tumor infiltrating lymphocytes (TILs)
资金
- National Natural Science Foundation of China [81802255]
- Shanghai Pujiang Program [17PJD036]
- Shanghai Municipal Commission of Health and Family Planning Program [20174Y0131]
- National key research & development project [2016YFC0902300]
- Major disease clinical skills enhancement program of three year action plan for promoting clinical skills and clinical innovation in municipal hospitals
- Shanghai Shen Kang Hospital Development Center Clinical Research Plan of SHDC [16CR1001A]
- Dream Tutor Outstanding Young Talents Program [fkyq1901]
- key disciplines of Shanghai Pulmonary Hospital [2017ZZ02012]
- Shanghai Science and Technology Commission [16JC1405900]
Background: Immunotherapy has shown promising effect for non-small cell lung cancer (NSCLC) patients. Yet the biomarkers for predicting immunotherapy efficiency are still lacking. Methods: We tested 139 surgical resected NSCLC primary tumor samples from Medical University of Gdansk, Poland, for T cell immunoglobulin and mucin-domain containing-3 (TIM-3) level by immunohistochemistry (IHC), analyzed the expression of TIM-3 protein on NSCLC tumor cells and tumor infiltrating lymphocytes (TILs). Results: TIM-3 on TILs was correlated with programmed cell death protein-1 (PD-1) on TILs (correlation coefficient =0.346, P<0.001) and programmed cell death protein-ligand 1 (PD-L1) on TILs (correlation coefficient =0.313, P<0.001), PD-L1 level on tumor cells (correlation coefficient =0.255, P=0.002), TIM-3 level on tumor cells (correlation coefficient =0.262, P=0.002) and TIL percentage (correlation coefficient =0.172, P=0.043). TIM-3 level on tumor cells only had correlation with PD-L1 level (correlation coefficient =0.170, P=0.045). High level of TIM-3 on TILs indicated shorter recurrence-free survival (RFS) and overall survival (OS) (RFS 1.800 years, 95% CI, 1.230-2.370 vs. 0.870 years, 95% CI, 0.212-1.528, P=0.048) (OS 2.960 years, 95% CI, 2.268-3.652 vs. 1.080 years, 95% CI, 0.228-1.932, P=0.034). Conclusions: TIM-3 is expressed on NSCLC tumor cells and TILs in all NSCLC pathological type. TIM-3 level on TILs had correlation with PD-1 and PD-L1 level. NSCLC patients with high TIM-3 level on TILs were more likely to have poor prognosis.
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