期刊
CARBOHYDRATE POLYMERS
卷 147, 期 -, 页码 473-481出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.04.021
关键词
Hydrogel; Transdermal delivery system; Hyaluronic acid; Isoliquiritigenin
资金
- Korean Health Technology R&D Project, Ministry of Health&Welfare, Republic of Korea [HN15C0104]
In the present study, the properties of hydrogel systems based on hyaluronic acid (HA)-hydroxyethyl cellulose (HEC) were investigated for effective transdermal delivery of isoliquiritigenin (ILTG). Hydrogels were synthesized by chemical cross-linking, and network structures were characterised using scanning electron microscopy (SEM) and surface area analyser. Texture properties and swelling of HA-HEC hydro gels were found to be closely linked to cross-linker concentration and swelling medium. Water in HA-HEC hydrogels was found to exist mostly in the form of free water. The viscoelasticity and the network stabilization of the hydrogels were analysed via rheological studies. The release kinetics of the hydrogel followed Fickian diffusion mechanism. In an in vitro skin penetration study, the system substantially improved the delivery of ILTG into the skin. These results indicate that the hydrogel system composed of HA and HEC has potential as a transdermal delivery system, with cross-linking density and the swelling medium influencing the properties. (C) 2016 Elsevier Ltd. All rights reserved.
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