期刊
CARBOHYDRATE POLYMERS
卷 136, 期 -, 页码 560-569出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.09.065
关键词
Garlic polysaccharide; Selenylation modification; Lymphocyte proliferation; Cytokines Immune response
资金
- National Natural Science Foundation of China [31272596]
- Special Fund for Agro-scientific Research in the Public Interest [201403051]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Key Scientific and Technological Grant from Shanxi Province [2010311047]
Garlic polysaccharide (GPS) was modified in selenylation respectively by nitric acid-sodium selenite (NA-SS), glacial acetic acid-selenous acid (GA-SA), glacial acetic acid-sodium selenite (GA-SS) and selenium oxychloride (SOC) methods each under nine modification conditions of L-9 (3(4)) orthogonal design and each to obtain nine selenizing GPSs (sGPSs). Their structures were identified, yields and selenium contents were determined, selenium yields were calculated, and the immune-enhancing activities of four sGPSs with higher selenium yields were compared taking unmodified GPS as control. The results showed that among four methods the selenylation efficiency of NA-SS method were the highest, the activity of sGPS(5) was the strongest and significantly stronger than that of unmodified GPS. This indicates that selenylation modification can significantly enhance the immune-enhancing activity of GPS, NA-SS method is the best method and the optimal conditions are 0.8:1 weight ratio of sodium selenite to GPS, reaction temperature of 70 degrees C and reaction time of 10 h. (C) 2015 Elsevier Ltd. All rights reserved.
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