期刊
CARBOHYDRATE POLYMERS
卷 141, 期 -, 页码 175-183出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.12.064
关键词
Chitosan; Gelatin; Hydrogel; Scaffold; Unidirectional freezing; Biomaterial
资金
- Xunta de Galicia [GRC2013-044]
Chitosan and gelatin are biodegradable and biocompatible polymers which may be used in the preparation of 3D scaffolds with applications in biomedicine. Chitosan/gelatin scaffolds crosslinked with glutaraldehyde were prepared by ice segregation induced self-assembly (ISISA); a unidirectional freezing at -196 degrees C followed freeze-drying to produce macroporous materials with a well-patterned structure. This process may be included within the green chemistry by the preparation of the porous structures without using organic solvents, moreover is a versatile, non-difficult and cheap process. The scaffolds prepared by ISISA were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, and their stability was evaluated by degree swelling and degradation tests. The scaffolds present properties as high porosity, high degree swelling and good stability which make them suitable of applications as biomaterials. (C) 2015 Elsevier Ltd. All rights reserved.
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