期刊
CARBOHYDRATE POLYMERS
卷 152, 期 -, 页码 832-840出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.07.042
关键词
Chitosan; Chitin nanocrystal; Scaffold; Compressive property; Biocompatibility
资金
- National High Technology Research and Development Program of China [2015AA020915]
- National Natural Science Foundation of China [51473069, 51502113]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014606]
- Science and Technology Planning Project of Guangdong Province [2014A020217006]
- Guangdong Special support program [2014TQ01C127]
- Special Fund for Ocean-Scientific Research in the public interest [201405105]
- Fundamental Research Funds for the Central Universities [21615204]
Chitin nanocrystals (CNCs) with length and width of 300 and 20 nm were uniformly dispersed in chitosan (CS) solution. The CS/CNCs composite scaffolds prepared utilizing a dispersion-based freeze dry approach exhibit significant enhancement in compressive strength and modulus compared with pure CS scaffold both in dry and wet state. A well-interconnected porous structure with size in the range of 100-200 mu m and over 80% porosity are found in the composite scaffolds. The crystal structure of CNCs is retained in the composite scaffolds. The incorporation of CNCs leads to increase in the scaffold density and decrease in the water swelling ratio. Moreover, the composite scaffolds are successfully applied as scaffolds for MC3T3-E1 osteoblast cells, showing their excellent biocompatibility and low cytotoxicity. The results of fluorescent micrographs images reveal that CNCs can markedly promote the cell adhesion and proliferation of the osteoblast on CS. The biocompatible composite scaffolds with enhanced mechanical properties have potential application in bone tissue engineering. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据