期刊
NATURE BIOMEDICAL ENGINEERING
卷 4, 期 3, 页码 259-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-019-0494-0
关键词
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资金
- National Key Research and Development Program of China [2017YFA0205200, 2016YFC0102600]
- National Natural Science Foundation of China (NSFC) [81930053, 61622117, 81671759, 81227901]
- Chinese Academy of Sciences [GJJSTD20170004]
- Beijing Natural Science Foundation [JQ19027]
- Beijing Nova Program [Z181100006218046]
- Scientific Instrument Developing Project of the Chinese Academy of Sciences [YZ201672]
- innovative research team of high-level local universities in Shanghai
- Zhuhai High-level Health Personnel Team Project [Zhuhai HLHPTP201703]
The second near-infrared wavelength window (NIR-II, 1,000-1,700 nm) enables fluorescence imaging of tissue with enhanced contrast at depths of millimetres and at micrometre-scale resolution. However, the lack of clinically viable NIR-II equipment has hindered the clinical translation of NIR-II imaging. Here, we describe an optical-imaging instrument that integrates a visible multispectral imaging system with the detection of NIR-II and NIR-I (700-900 nm in wavelength) fluorescence (by using the dye indocyanine green) for aiding the fluorescence-guided surgical resection of primary and metastatic liver tumours in 23 patients. We found that, compared with NIR-I imaging, intraoperative NIR-II imaging provided a higher tumour-detection sensitivity (100% versus 90.6%; with 95% confidence intervals of 89.1%-100% and 75.0%-98.0%, respectively), a higher tumour-to-normal-liver-tissue signal ratio (5.33 versus 1.45) and an enhanced tumour-detection rate (56.41% versus 46.15%). We infer that combining the NIR-I/II spectral windows and suitable fluorescence probes might improve image-guided surgery in the clinic. An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.
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