期刊
CARBOHYDRATE POLYMERS
卷 140, 期 -, 页码 163-170出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.12.010
关键词
Calcium alginate beads; Cross-linked calcium; Non-cross-linked calcium; Encapsulation efficiency; Mucoadhesiveness; Drug release
In this study, ibuprofen-loaded calcium alginate beads (CABs) with varying amounts of non-cross-linked calcium (NCL-Ca) were prepared using different washing methods. The influence of NCL-Ca on beads properties was investigated. Increasing the number or duration of washes led to significant decreases in the amount of NCL-Ca whereas the impact of the volume of washes was not significant. Approximately 70% of the initial amount of Ca2+ was NCL-Ca which was removable by washing while only 30% was cross-linked (CL-Ca). Ca2+ release from the CABs was bimodal; NCL-Ca2+ was burst-released followed by a slower release of CL-Ca. Washing methods and the amount of NCL-Ca2+ had significant influences on the encapsulation efficiency, beads weight, beads swelling, drug release profile and the mucoadhesiveness of CABs. This study highlighted the importance of washing methods and the amount of NCL-Ca to establish CABs properties and understand their behaviour in the simulated intestinal fluids (SIFs). (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据