期刊
CARBOHYDRATE POLYMERS
卷 137, 期 -, 页码 625-631出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.11.023
关键词
Radix Polygoni Multiflori; Water extracted residues; Alkali extractable polysaccharides; Immunomodulatory activity
资金
- National Natural Science Foundation of China (NSFC) [21375156]
- Ministry of Science and Technology of the People's Republic of China 863 Plan [2015AA021104]
The alkali-extractable polysaccharides (APMPs) were isolated from the water extracted residues of Radix Polygoni Multiflori, and further purified by DEAE-52 cellulose and Sephadex G-100 column chromatography to obtain a homogeneous polysaccharide (APMP-2) with molecular weights of 7724.8 Da. HPLC chromatography analysis identified that APMP-2 was a heteropolysaccharides and mainly composed of Galactose and Xylose with a molar ratio of 4.31: 1.06. It was shown that both APMP and APMP-2 were of activation effects on splenocytes and peritoneal macrophages, and also significantly restore the proliferation rate, phagocytic index and cytokine (IL-2 and TNF-alpha) production level of 5-FU-treated splenocytes/peritoneal macrophages in a dosage-dependent manner. The results suggested that polysaccharides presented in Radix Polygoni Multiflori water-extracted residues possessed immunomodulatory activity and could be used as potential immunomodulators, and this finding could be a reference for the utilization of Radix Polygoni Multiflori water extracted residues. (C) 2015 Elsevier Ltd. All rights reserved.
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