期刊
CARDIOLOGY RESEARCH AND PRACTICE
卷 2019, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2019/5019287
关键词
-
资金
- Russian Scientific Foundation [18-15-00222]
- Russian Science Foundation [18-15-00222] Funding Source: Russian Science Foundation
Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present the fibrotic concept of the etiology and pathogenesis of preeclampsia which involves system consisting of Na/K-ATPase and its endogenous ligands including marinobufagenin. New therapy of preeclampsia includes modulation of the Na/K-ATPase system by immunoneutralization of the marinobufagenin and use of mineralocorticoid antagonists which are capable to impair marinobufagenin-Na/K-ATPase interactions.
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