期刊
CARBOHYDRATE POLYMERS
卷 151, 期 -, 页码 172-188出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.05.049
关键词
Biomaterials; Chitosan; Stem cells; Osteoblasts; Bone tissue engineering
资金
- Council of Scientific and Industrial Research (CSIR), India [60(0110)/13/EMR-II]
- SRM University
Critical-sized bone defects treated with biomaterials offer an efficient alternative to traditional methods involving surgical reconstruction, allografts, and metal implants. Chitosan, a natural biopolymer is widely studied for bone regeneration applications owing to its tunable chemical and biological properties. However, the potential of chitosan to repair bone defects is limited due to its water insolubility, faster in vivo depolymerization, hemo-incompatibility, and weak antimicrobial property. Functionalization of chitosan structure through various chemical modifications provides a solution to these limitations. In this review, current trends of using chitosan as a composite with other polymers and ceramics, and its modifications such as quaternization, carboxyalkylation, hydroxylation, phosphorylation, sulfation and copolymerization in bone tissue engineering are elaborated. (C) 2016 Elsevier Ltd. All rights reserved.
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