期刊
CARBOHYDRATE POLYMERS
卷 144, 期 -, 页码 390-399出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.080
关键词
Chitosan; Glaucoma; Latanoprost; Sustained release
资金
- Ministry of Science and Technology [MOST104-2325-B-010-006]
- Department of Health, Taipei City Government
Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment. (C) 2016 Elsevier Ltd. All rights reserved.
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