期刊
CARBOHYDRATE POLYMERS
卷 136, 期 -, 页码 1161-1169出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.10.035
关键词
Lactobacillus crispatus; Fructo-oligosaccharide; Ascorbic acid; In situ gelling inserts; Mucoadhesion; Vaginal release
The aim of this work was to develop a synbiotic vaginal insert containing the probiotic strain Lactobacillus crispatus BC5, the prebiotic substrate fructo-oligosaccharide and the antioxidant agent ascorbic acid, for the prophylaxis and therapy of vaginal infections. Mucoadhesive in situ gelling vaginal inserts based on hydroxypropyl methylcellulose were prepared by freeze-drying, stored at +2-8 degrees C for 90 days and characterized in terms of technological and functional properties. Complete survival of L. crispatus BC5 was found immediately after insert preparation (96.08%) as well as after 90 days of storage (95.82%) in the vaginal inserts containing fructo-oligosaccharide, ascorbic acid and skimmed milk. Synbiotic inserts showed improved mucoadhesion ability (from three- to five-fold) with respect to a standard formulation based on hydroxypropyl methylcellulose alone. Moreover, inserts allowed to modulate lactobacilli release in virtue of the different amounts of fructo-oligosaccharide. Finally, antimicrobial activity was exerted by L. crispatus BC5 released from the vaginal formulation. (c) 2015 Elsevier Ltd. All rights reserved.
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