期刊
OPEN FORUM INFECTIOUS DISEASES
卷 7, 期 3, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofaa042
关键词
antibiotic resistance; fecal microbiota transplant; microbial restoration therapy; microbiome; urinary tract infection
资金
- US Centers for Disease Control and Prevention Epicenter Prevention Program [U54CK000482]
- Longer Life Foundation: A RGA/Washington University Partnership
- National Center for Advancing Translational Sciences [KL2TR002346, UL1TR002345]
- National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) [K23A1137321]
- NIAID [R01AI123394]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development of the NIH [R01HD092414]
- National Science Foundation [DGE-1143945]
A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.
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