期刊
CARBOHYDRATE POLYMERS
卷 146, 期 -, 页码 320-327出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.03.068
关键词
Chitin nanofibril; Atopic dermatitis; Corticosteroids; Nuclear factor-kappa B; Cyclooxygenase-2; Inducible nitric oxide synthase
资金
- Advanced Research and Technology (START) project ofJST
- KAKENHI of JSPS [26708026]
- Grants-in-Aid for Scientific Research [16K05915, 26708026] Funding Source: KAKEN
We evaluated the effect of chitin nanofibril (CNF) application via skin swabs on an experimental atopic dermatitis (AD) model. AD scores were lower, and hypertrophy and hyperkeratosis of the epidermis were suppressed after CNF treatment. Furthermore, inflammatory cell infiltration in both the epidermis and dermis was inhibited. CNFs also attenuated histological scores. The suppressive effects of CNFs were equal to those of corticosteroid application; however, chitin did not show these effects. CNF application might have antiinfllammatory effects via suppression of the activation of nuclear factor -kappa B, cyclooxygenase-2, and inducible nitric oxide synthase. In an early-stage model of experimental AD, CNFs suppressed AD progression to the same extent as corticosteroids. They also suppressed skin inflammation and IgE serum levels. Our findings indicate that CNF application could aid in the prevention or treatment of AD skin lesions. (C) 2016 Elsevier Ltd. All rights reserved.
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