期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 18, 期 -, 页码 501-508出版社
ELSEVIER
DOI: 10.1016/j.csbj.2020.02.010
关键词
Intron retention; mRNA splicing; Bioinformatics; RNA sequencing; Gene expression
资金
- Agence Nationale de la Recherche [ANRJCJC -WIRED]
- Labex EpiGenMed [ANR-10-LABX-12-01]
- MUSE initiative [GECKO]
Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA. An increasing body of literature has demonstrated a major role for IR in numerous biological functions and in disease. Here we give an overview of the different computational approaches for detecting IR events from sequencing data. Weshow that these are based on different biological and computational assumptions that may lead to dramatically different results. We describe the various approaches for mitigating errors in detecting intron retention and for discovering IR signatures between different conditions. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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