期刊
JOURNAL OF ADVANCED RESEARCH
卷 21, 期 -, 页码 177-185出版社
ELSEVIER
DOI: 10.1016/j.jare.2019.10.007
关键词
Geometric morphometrics; Osteogenesis imperfecta; Pulmonary function; Rib cage; Scoliosis; Thoracic spine
资金
- Fundacion Eresa [BF14_005]
- Ministry of Economy, Industry and Competitiveness [CGL2015-63648-P]
- Care4Brittle-bones Foundation [OTR2016-15543INVES]
- University of Valencia [UV-INV_AE18-773873]
The aim of the present study was to test the hypothesis that ribs shape changes in patients with OI are more relevant for respiratory function than thoracic spine shape. We used 3D geometric morphometrics to quantify rib cage morphology in OI patients and controls, and to investigate its relationship with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), expressed as absolute value and as percentage of predicted value (% pred). Regression analyses on the full sample showed a significant relation between rib shape and FEV1, FVC and FVC % pred whereas thoracic spine shape was not related to any parameter. Subsequent regression analyses on OI patients confirmed significant relations between dynamic lung volumes and rib shape changes. Lower FVC and FEV1 values are identified in OI patients that present more horizontally aligned ribs, a greater antero-posterior depth due to extreme transverse curve at rib angles and a strong spine invagination, greater asymmetry, and a vertically short, thoracolumbar spine, which is relatively straight in at levels 1-8 and shows a marked kyphosis in the thoraco-lumbar transition. Our research seems to support that ribs shape is more relevant for ventilator mechanics in OI patients than the spine shape. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
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