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NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer
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FRONTIERS IN ONCOLOGY (2019)
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling
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AGING-US (2019)
Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)
Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway
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NUCLEIC ACIDS RESEARCH (2019)
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
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PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
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CANCERS (2019)
IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
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BLOOD (2019)
Increased nicotinamide adenine dinucleotide pool promotes colon cancer progression by suppressing reactive oxygen species level
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CANCER SCIENCE (2019)
Genomic and tumor biological aspects of the anticancer nicotinamide phosphoribosyltransferase inhibitor FK866 in resistant human colorectal cancer cells
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GENOMICS (2019)
High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor
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EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target
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MEDICAL ONCOLOGY (2019)
Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
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Oncotarget (2019)
Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia
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BLOOD ADVANCES (2019)
Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenstrom Macroglobulinemia
Na Li et al.
CLINICAL CANCER RESEARCH (2019)
Rho GTPase effectors and NAD metabolism in cancer immune suppression
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EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype
Mickael Ohanna et al.
GENES & DEVELOPMENT (2018)
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
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JOURNAL OF CLINICAL INVESTIGATION (2018)
Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway
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LEUKEMIA RESEARCH (2018)
The role of extracellular and intracellular Nicotinamide phosphoribosyl-transferase in cancer: Diagnostic and therapeutic perspectives and challenges
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METABOLISM-CLINICAL AND EXPERIMENTAL (2018)
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition
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MOLECULAR & CELLULAR PROTEOMICS (2018)
Expression of NAMPT is associated with breast invasive ductal carcinoma development and prognosis
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ONCOLOGY LETTERS (2018)
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
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Oncotarget (2018)
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools
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MOLECULAR CANCER RESEARCH (2018)
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
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NATURE (2018)
Genotype-targeted local therapy of glioma
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The NAD(+) Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis
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CELL REPORTS (2018)
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells
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ONCOLOGY LETTERS (2018)
Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model
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MOLECULAR AUTISM (2018)
NAD Metabolism in Cancer Therapeutics
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FRONTIERS IN ONCOLOGY (2018)
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites
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CELL CHEMICAL BIOLOGY (2018)
NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP
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CLINICAL CANCER RESEARCH (2018)
Selective Cytotoxicity of the NAMPT Inhibitor FK866 Toward Gastric Cancer Cells With Markers of the Epithelial-Mesenchymal Transition, Due to Loss of NAPRT
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GASTROENTEROLOGY (2018)
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AUTOPHAGY (2017)
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ONCOLOGY REPORTS (2017)
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PEPTIDES (2017)
Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells
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ONCOTARGET (2017)
Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer
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ONCOTARGET (2017)
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ONCOTARGET (2017)
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JOURNAL OF IMMUNOLOGY RESEARCH (2017)
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CLINICAL CANCER RESEARCH (2017)
The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
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CELL BIOCHEMISTRY AND FUNCTION (2017)
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
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CANCER RESEARCH (2017)
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity
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CANCER RESEARCH (2017)
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma
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ANTICANCER RESEARCH (2017)
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
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CELL DEATH AND DIFFERENTIATION (2016)
NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer
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ONCOGENE (2016)
Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer
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ONCOLOGY REPORTS (2016)
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
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ONCOTARGET (2016)
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CANCER LETTERS (2016)
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CLINICAL CANCER RESEARCH (2016)
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MOLECULAR CANCER THERAPEUTICS (2016)
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
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BIOMED RESEARCH INTERNATIONAL (2016)
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JAMA DERMATOLOGY (2016)
Nicotinamide Phosphoribosyltransferase and SirT3 Expression are increased in Well-Differentiated Thyroid Carcinomas
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AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2016)
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PLOS ONE (2016)
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MOLECULAR & CELLULAR ONCOLOGY (2016)
NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells
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CHINESE JOURNAL OF NATURAL MEDICINES (2016)
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
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EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition
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BMC CANCER (2015)
Extreme Vulnerability of IDH1 Mutant Cancers to NAD plus Depletion
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CLINICAL CANCER RESEARCH (2015)
Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S-Nampt
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EXPERIMENTAL CELL RESEARCH (2015)
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Physiological and pathophysiological roles of NAMPT and NAD metabolism
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Visfatin promotes osteosarcoma cell migration and invasion via induction of epithelial-mesenchymal transition
Gong Cheng et al.
ONCOLOGY REPORTS (2015)
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
Deepak Sampath et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma
Ambra A. Grolla et al.
PIGMENT CELL & MELANOMA RESEARCH (2015)
Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression
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TUMOR BIOLOGY (2015)
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by beta-lapachone
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CELL DEATH & DISEASE (2015)
Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer
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JOURNAL OF CANCER (2015)
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia
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NATURE REVIEWS CANCER (2015)
Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy
Ping Yang et al.
PHARMAZIE (2015)
Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non-Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption
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CANCER RESEARCH (2014)
BRCA1 as a nicotinamide adenine dinucleotide (NAD)-dependent metabolic switch in ovarian cancer
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Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors
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CLINICAL CANCER RESEARCH (2014)
On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells
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CLINICAL CANCER RESEARCH (2014)
Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer
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JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells
Vladimir Tolstikov et al.
PLOS ONE (2014)
NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study
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RADIOTHERAPY AND ONCOLOGY (2014)
NAD+ and sirtuins in aging and disease
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TRENDS IN CELL BIOLOGY (2014)
NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples
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SCIENTIFIC REPORTS (2014)
Intracellular NAD+ depletion induces autophagic death in multiple myeloma cells
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AUTOPHAGY (2013)
Intracellular NAD(H) levels control motility and invasion of glioma cells
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Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
David S. Shames et al.
CLINICAL CANCER RESEARCH (2013)
Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience
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NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity
Sathisha Upparahalli Venkateshaiah et al.
EXPERIMENTAL HEMATOLOGY (2013)
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
Basant Kumar Thakur et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients
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CANCER DISCOVERY (2013)
Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618
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NEOPLASIA (2013)
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
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BLOOD (2012)
Nampt/Visfatin/PBEF: A Functionally Multi-faceted Protein with a Pivotal Role in Malignant Tumors
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CURRENT PHARMACEUTICAL DESIGN (2012)
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
Ilirjana Bajrami et al.
EMBO MOLECULAR MEDICINE (2012)
Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase
Li-Yuan Zhang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53-and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Nicotinamide Phosphoribosyltransferase: A Potent Therapeutic Target in Non-small Cell Lung Cancer with Epidermal Growth Factor Receptor-Gene Mutation
Shunsuke Okumura et al.
JOURNAL OF THORACIC ONCOLOGY (2012)
Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells
Sarah C. Bowlby et al.
PLOS ONE (2012)
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
Antje Menssen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Nampt is involved in DNA double-strand break repair
Bingtao Zhu et al.
CHINESE JOURNAL OF CANCER (2012)
The NAD metabolome - a key determinant of cancer cell biology
Alberto Chiarugi et al.
NATURE REVIEWS CANCER (2012)
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas
Uffe Hogh Olesen et al.
APMIS (2011)
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
B. Wang et al.
ONCOGENE (2011)
Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil
Tie-Qiang Bi et al.
ONCOLOGY REPORTS (2011)
Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD+ synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3
Kazumi Ishidoh et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data
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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)
The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer
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CANCER RESEARCH (2010)
A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity
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EXPERIMENTAL BIOLOGY AND MEDICINE (2010)
Potent synergistic interaction between the Nampt inhibitor AP0866 and the apoptosis activator TRAIL in human leukemia cells
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EXPERIMENTAL HEMATOLOGY (2010)
A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor
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MOLECULAR CANCER THERAPEUTICS (2010)
Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
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MOLECULAR AND CELLULAR BIOLOGY (2009)
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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JOURNAL OF CLINICAL ONCOLOGY (2008)
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