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The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells
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JOURNAL OF CELL SCIENCE (2005)
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
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CELL (2005)
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SCIENCE (2005)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
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NATURE CELL BIOLOGY (2004)
Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion
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JOURNAL OF BIOCHEMISTRY (2003)
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
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JOURNAL OF CELL SCIENCE (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
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CURRENT BIOLOGY (2003)
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α):: Transcriptional coactivator and metabolic regulator
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ENDOCRINE REVIEWS (2003)
Construction of a protein-detection system using a loop peptide library with a fluorescence label
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CHEMISTRY & BIOLOGY (2003)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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NATURE CELL BIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
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CELL (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
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MOLECULAR CELL (2002)
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
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BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2002)
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), a novel PGC-1-related transcription coactivator associated with host cell factor
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
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NATURE GENETICS (2000)
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)