期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 15, 期 4, 页码 449-460出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2019.11.006
关键词
Heparins; Oral delivery; Multiple obstacles; Stability; Intestinal epithelia permeability; Lymphatic transport
资金
- Natural Science Fund for Colleges and Universities in Jiangsu Province [17KJB350009]
- Natural Science Foundation of Jiangsu Province [BK20170445]
Heparins show great anticoagulant effect with few side effects, and are administered by subcutaneous or intravenous route in clinics. To improve patient compliance, oral administration is an alternative route. Nonetheless, oral administration of heparins still faces enormous challenges due to the multiple obstacles. This review briefly analyzes a series of barriers ranging from poorly physicochemical properties of heparins, to harsh biological barriers including gastrointestinal degradation and pre-systemic metabolism. Moreover, several approaches have been developed to overcome these obstacles, such as improving stability of heparins in the gastrointestinal tract, enhancing the intestinal epithelia permeability and facilitating lymphatic delivery of heparins. Overall, this review aims to provide insights concerning advanced delivery strategies facilitating oral absorption of heparins. (C) 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V.
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