期刊
CELLS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells9030544
关键词
PP2A; MYC; myeloid leukemia; AML; CML
类别
资金
- ISCIII
- Spanish Ministry of Economy and Competiveness [PI17/02272]
- CIBERONC [CB16/12/00489]
- Departamento de Salud of the Government of Navarra [29/2015]
- Departamento de Desarrollo Economico of the Government of Navarra [PI020 PDX-AML]
- Prostate Cancer Foundation
- FEDER funds
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other's activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.
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