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Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

期刊

CELLS
卷 9, 期 2, 页码 -

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MDPI
DOI: 10.3390/cells9020521

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tumor suppressor miRNA; cancer therapy; nanoparticle delivery

资金

  1. National Breast Cancer Research Institute (NBCRI)

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Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.

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