期刊
CELLS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells9020311
关键词
aggrephagy; selective autophagy; Alzheimer's disease; aggregates
类别
资金
- National Natural Science Foundation of China [NSFC/81773926, NSFC/81703487]
- Hong Kong General Research Fund [HKBU121006/18, HKBU121014/17]
- Hong Kong Health and Medical Fund [HMRF15163481, HMRF14150811]
- Hong Kong Baptist University Research Fund [HKBU/RC-IRCs/17-18/03, HKBU/RC-IRMS/15-16/04, FRGII/17-18/021, FRGII/16-17/018]
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (A beta and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.
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