相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Metformin Treatment Suppresses Melanoma Cell Growth and Motility through Modulation of microRNA Expression
Hui-Wen Tseng et al.
CANCERS (2019)
A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic
Wei Liu et al.
CANCER SCIENCE (2019)
Metformin Prevents Peritoneal Dissemination via Immune-suppressive Cells in the Tumor Microenvironment
Takanori Hirayama et al.
ANTICANCER RESEARCH (2019)
Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
Takenori Uehara et al.
INTERNATIONAL IMMUNOLOGY (2019)
Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
Serena Saladini et al.
CELLS (2019)
Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
Mingzhu Bai et al.
ONCOGENE (2018)
Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner
Meital Charni-Natan et al.
CELL DEATH & DISEASE (2018)
Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors
Toshio Kubo et al.
CLINICAL LUNG CANCER (2018)
Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling
Peng Shen et al.
MOLECULAR ONCOLOGY (2018)
Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial
Yan Fu et al.
EBIOMEDICINE (2017)
Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab
Elisabet Cuyas et al.
CELL CYCLE (2017)
Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis
Dali Tong et al.
CANCER LETTERS (2017)
Metformin Enhances the Therapy Effects of Anti-IGF-1R mAb Figitumumab to NSCLC
Hongxin Cao et al.
SCIENTIFIC REPORTS (2016)
Metformin Action: Concentrations Matter
Ling He et al.
CELL METABOLISM (2015)
The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation
Xin-an Lu et al.
BIOCHEMICAL JOURNAL (2014)
Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
Akimasa Takahashi et al.
CANCER CELL INTERNATIONAL (2014)
Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
Li Li et al.
CLINICAL CANCER RESEARCH (2014)
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
Giorgia Zadra et al.
EMBO MOLECULAR MEDICINE (2014)
Ethyl pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain
Joo-Hyun Shin et al.
NEUROSCIENCE LETTERS (2014)
PLCγ1-PKCγ Signaling-Mediated Hsp90α Plasma Membrane Translocation Facilitates Tumor Metastasis
Jian Yang et al.
TRAFFIC (2014)
Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
Y. Feng et al.
CELL DEATH & DISEASE (2014)
An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein
Jessica McCready et al.
CANCERS (2014)
Secreted Heat Shock Protein 90α (HSP90α) Induces Nuclear Factor-κB-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion
Wei-Shone Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo
Fred Tsen et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
Wei Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation
Lianru Zhang et al.
CELLULAR SIGNALLING (2012)
Protection against Ischemia-Induced Oxidative Stress Conferred by Vagal Stimulation in the Rat Heart: Involvement of the AMPK-PKC Pathway
Shan-Shan Kong et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme
Anjali A. Sarkar et al.
JOURNAL OF CELL BIOLOGY (2012)
Protein kinase C, an elusive therapeutic target?
Daria Mochly-Rosen et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator
Kuen-Haur Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Secretome Compartment Is a Valuable Source of Biomarkers for Cancer-Relevant Pathways
Dario Caccia et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation
Jessica McCready et al.
BMC CANCER (2010)
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT) From cancer stem cells to aging-associated fibrosis
Silvia Cufi et al.
CELL CYCLE (2010)
PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis
Nabil Djouder et al.
EMBO JOURNAL (2010)
Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability
Suofu Qin et al.
EXPERIMENTAL EYE RESEARCH (2010)
Secreted Heat Shock Protein 90α Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-κB-mediated Integrin αV Expression
Jinn-Shiun Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis
Xiaomin Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Targeting the dynamic HSP90 complex in cancer
Jane Trepel et al.
NATURE REVIEWS CANCER (2010)
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
Irina N. Alimova et al.
CELL CYCLE (2009)
The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy
Xiaofeng Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford et al.
NATURE REVIEWS CANCER (2009)
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment
Li Zhong et al.
CANCER RESEARCH (2008)
Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells
Yanai Zhan et al.
CLINICAL CANCER RESEARCH (2008)
Transforming growth factor α (TGFα)-stimulated secretion of HSP90α:: Using the receptor LRF-1/CD91 to promote human skin cell migration against a TGFβ-rich environment during wound healing
Chieh-Fang Cheng et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion
S. Tsutsumi et al.
ONCOGENE (2008)
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
Ryan J. O. Dowling et al.
CANCER RESEARCH (2007)
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
Yasushi Kojima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
Monica Buzzai et al.
CANCER RESEARCH (2007)
AMP-activated protein kinase in metabolic control and insulin signaling
Mhairi C. Towler et al.
CIRCULATION RESEARCH (2007)
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
Mahvash Zakikhani et al.
CANCER RESEARCH (2006)
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
K Sakamoto et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
The HSP90 family of genes in the human genome: Insights into their divergence and evolution
B Chen et al.
GENOMICS (2005)
Metformin and reduced risk of cancer in diabetic patients
JMM Evans et al.
BMJ-BRITISH MEDICAL JOURNAL (2005)
Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness
BK Eustace et al.
NATURE CELL BIOLOGY (2004)
分享论文
