期刊
CELLS
卷 9, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells9010223
关键词
cancer therapy; EMT; lysosome; lysosome-mediated invasion; MZF1; phosphorylation; PAK4; SUMOylation; transcription factor; zinc finger
类别
资金
- Novo Nordisk Foundation [NNF15OC0017324]
- Danish Medical Research Council [0602-02386B]
- Danish Cancer Society Scientific Committee (KBVU) [R124-A7854-15-S2, R56-A3108-12-S2]
- Danish National Research Foundation [DNRF125]
Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients. This could be achieved by targeting the molecules regulating invasion. One of these is an oncogenic transcription factor, Myeloid Zinc Finger 1 (MZF1). Dysregulated transcription factors represent a unique, increasing group of drug targets that are responsible for aberrant gene expression in cancer and are important nodes driving cancer malignancy. Recent studies report of a central involvement of MZF1 in the invasion and metastasis of various solid cancers. In this review, we summarize the research on MZF1 in cancer including its function and role in lysosome-mediated invasion and in the expression of genes involved in epithelial to mesenchymal transition. We also discuss possible means to target it on the basis of the current knowledge of its function in cancer.
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