期刊
CELLS
卷 8, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells8121621
关键词
chromatin remodeling complex; SWR1-C; H2A.Z; flowering time regulation
类别
资金
- National Natural Science Foundation of China [U1605212, 31761130074, 31970333]
- Guangxi Distinguished Experts Fellowship [NA160391]
- Newton Advanced Fellowship [NA160391]
- Guangxi University
The nucleosome is the structural and fundamental unit of eukaryotic chromatin. The chromatin remodeling complexes change nucleosome composition, packaging and positioning to regulate DNA accessibility for cellular machinery. SWI2/SNF2-Related 1 Chromatin Remodeling Complex (SWR1-C) belongs to the INO80 chromatin remodeling family and mainly catalyzes the exchange of H2A-H2B with the H2A.Z-H2B dimer. The replacement of H2A.Z into nucleosomes affects nucleosome stability and chromatin structure. Incorporation of H2A.Z into the chromatin and its physiochemical properties play a key role in transcriptional regulation during developmental and environmental responses. In Arabidopsis, various studies have uncovered several pivotal roles of SWR1-C. Recently, notable progress has been achieved in understanding the role of SWR1-C in plant developmental and physiological processes such as DNA damage repair, stress tolerance, and flowering time. The present article introduces the SWR1-C and comprehensively reviews recent discoveries made in understanding the function of the SWR1 complex in plants.
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