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Tsg101 chaperone function revealed by HIV-1 assembly inhibitors
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Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy
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TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death
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Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease
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A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease
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A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy
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A Knockout of the Tsg101 Gene Leads to Decreased Expression of ErbB Receptor Tyrosine Kinases and Induction of Autophagy Prior to Cell Death
Chantey R. Morris et al.
PLOS ONE (2012)
Tumor Susceptibility Gene 101 (TSG101) Is a Novel Binding-Partner for the Class II Rab11-FIPs
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Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1
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TSG101, identified by screening a cancer cDNA library and soft agar assay, promotes cell proliferation in human lung cancer
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Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions
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Abnormal regulation of TSG101 in mice with spongiform neurodegeneration
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Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
Camilla Raiborg et al.
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Regulation of Tsg101 expression by the steadiness box: A role of Tsg101-associated ligase
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Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55
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Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation
K. B. Oh et al.
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Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer
Travis W. Young et al.
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Spongiform neurodegeneration-associated E3 ligase mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
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Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses
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Proteomics analyses of ovarian caner using genetically defined human ovarian cancer models
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Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation
M. Razi et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
KH Moberg et al.
DEVELOPMENTAL CELL (2005)
Depletion of TSG101 forms a mammalian 'Class E' compartment: a multicisternal early endosome with multiple sorting defects
A Doyotte et al.
JOURNAL OF CELL SCIENCE (2005)
A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila
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MOLECULAR BIOLOGY OF THE CELL (2005)
Reduction of TSG101 protein has a negative impact on tumor cell growth
G Zhu et al.
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Ubiquitin recognition by the human TSG101 protein
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MOLECULAR CELL (2004)
Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice
MD Henry et al.
ONCOGENE (2004)
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
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GENESIS (2004)
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation
KG Bache et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells
MJ Carstens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma
TK Man et al.
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Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding
I Amit et al.
GENES & DEVELOPMENT (2004)
The protein network of HIV budding
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CELL (2003)
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein
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JOURNAL OF CELL BIOLOGY (2003)
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
Q Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling
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Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein
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Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas
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Structure and functional interactions of the Tsg101 UEV domain
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EMBO JOURNAL (2002)
Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1
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Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates
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HIV-I and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
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Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
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CELL (2001)
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
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CELL (2001)
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag
L VerPlank et al.
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Proteomic analysis of dendritic cell-derived exosomes:: A secreted subcellular compartment distinct from apoptotic vesicles
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TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes
N Bishop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
LM Li et al.
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p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101
J Ruland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking
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TRAFFIC (2000)