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Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells

期刊

JOURNAL OF CLINICAL MEDICINE
卷 9, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/jcm9020310

关键词

Eph; Ephrin; MSC

资金

  1. Instituto de Salud Carlos III - (European Regional Development Fund/European Social Fund A way to make Europe/Investing in your future) [RD16/0011/0002]
  2. Comunidad de Madrid [B2017/BMD-3692]
  3. Ministerio de Ciencia, Innovacion y Universidades [RTI2018-093938-B-100]

向作者/读者索取更多资源

Mesenchymal stromal/stem cells (MSCs) have emerged as important therapeutic agents, owing to their easy isolation and culture, and their remarkable immunomodulatory and anti-inflammatory properties. However, MSCs constitute a heterogeneous cell population which does not express specific cell markers and has important problems for in vivo homing, and factors regulating their survival, proliferation, and differentiation are largely unknown. Accordingly, in the present article, we review the current evidence on the relationships between Eph kinase receptors, their ephrin ligands, and MSCs. These molecules are involved in the adult homeostasis of numerous tissues, and we and other authors have demonstrated their expression in human and murine MSCs derived from both bone marrow and adipose tissue, as well as their involvement in the MSC biology. We extend these studies providing new results on the effects of Eph/ephrins in the differentiation and immunomodulatory properties of MSCs.

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