期刊
CANCER TREATMENT REVIEWS
卷 50, 期 -, 页码 35-47出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2016.08.004
关键词
Cancer clinical trials; RNA therapeutics; Antisense oligonucleotides; miRNA; siRNA
类别
Recent advances in RNA delivery and target selection provide unprecedented opportunities for cancer treatment, especially for cancers that are particularly hard to treat with existing drugs. Small interfering RNAs, microRNAs, and antisense oligonucleotides are the most widely used strategies for silencing gene expression. In this review, we summarize how these approaches were used to develop drugs targeting RNA in human cells. Then, we review the current state of clinical trials of these agents for different types of cancer and outcomes from published data. Finally, we discuss lessons learned from completed studies and future directions for this class of drugs. (C) 2016 Elsevier Ltd. All rights reserved.
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