期刊
BIOTECHNOLOGY ADVANCES
卷 33, 期 6, 页码 948-961出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.06.006
关键词
Microfluidics; Live-cell microarrays; Lab-on-a-chip; Organ-on-a-chip; Body-on-a-chip
资金
- Vienna Science and Technology Fund (WWTF) [LS13-092]
Microfluidic live-cell microarrays show much promise as screening tools for biomedical research because they could shed light on key biological processes such as cell signaling and cell-to-cell and cell-to-substrate dynamic responses. While miniaturization reduces the need for expensive clinical grade reagents, the integration of functional components including micropumps, biosensors, actuators, mixers and gradient generators results in improved assay reliability, reproducibility and well-defined cell culture conditions. The present review addresses recent technological advances in microfluidic live-cell microarray technology with a special focus on the applications of microfluidic single-cell, multi-cell and 3D cell microarrays. (C) 2015 Elsevier Inc All rights reserved.
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