期刊
SCIENCE ADVANCES
卷 6, 期 10, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aau4819
关键词
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资金
- multicenter U01 grant from the National Institute of Allergy and Infectious Disease [U01 AI 078045/MAC]
- Texas Health Catalyst award from The University of Texas at Austin Dell Medical School
- UT Mentoring Diversity Fellowship
- Williams and McGinity Graduate Fellowship
- Kuhn Family Scholars Award
A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an amorphous solid with a glass transition above room temperature and nitrogen-hydrogen bonding between virus and film components are critical determinants of stability. Administration of live influenza virus in the optimized film by the sublingual and buccal routes induced antibody-mediated immune responses as good as or better than those achieved by intramuscular injection. This work introduces the possibility of improving global access to a variety of medicines by offering a technology capable of reducing costs of production, distribution, and supply chain maintenance.
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