期刊
CHEM
卷 6, 期 1, 页码 266-279出版社
CELL PRESS
DOI: 10.1016/j.chempr.2019.11.009
关键词
-
资金
- National Natural Science Foundation of China [21772121, 21971163]
Here, we report a general catalytic manifold for the selective C-C bond scission of ketones via the exploitation of the ligand-to-metal charge transfer (LMCT) excitation mode. Through a cooperative utilization of Lewis acid catalysis and LMCT catalysis, the C-C bond of ketones could be selectively and effectively cleaved, enabling the installation of different functionalities at each carbon of the cleaved C-C bond through a sequential and orthogonal manner. This reaction manifold serves as a photocatalytic alternative to the Norrish type I reaction with the combination of visible light and inexpensive cerium salts. Under operationally simple conditions, a wide range of acyclic and cyclic ketones, from simple strained cyclobutanones to complex androsterone with less strained cyclopentanone moiety, could be successfully transformed into versatile chemical building blocks.
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