期刊
CHEMISTRYSELECT
卷 5, 期 1, 页码 156-164出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201903628
关键词
Differential pulse voltammetry; Non-enzymatic detection; Polydopamine; polypyrrole copolymer; Sensor; Uric acid
资金
- Centre of Excellence for Advanced Materials Research (CEAMR) King Abdulaziz University Jeddah, Kingdom of Saudi Arabia
Uric acid is mainly produced from metabolism of purine nucleotide in human body and have several medical importance in human system. It is therefore very imperative to develop a sensitive and accurate method of its detection. This study aimed to develop uric acid biosensor based on polydopamine/polypyrole (PDA/PPY) composite decorated on glassy carbon electrode. The conductive polymer PDA/PPY was electrochemically synthesized and casted on glassy carbon electrode (GCE). The synthesized PDA/PPY was characterized by fourier transform infrared spectroscopy, field emission scanning electron microscopy, electrochemical impedance spectroscopy, energy dispersive x-ray spectroscopy and x-ray photoelectron spectroscopy. PDA/PPY/GCE showed good response towards uric acid with low limit of detection (0.1 mu M, S/N =3), good linearity (0.5-40 mu M) and high sensitivity (2.1 mu A mu Mcm(-2)). It was also found to have stable response for uric acid unaffected by common interferents. Also, when used for uric acid detection in human serum and urine, it showed a good recovery of 90-110%. The developed PDA/PPY composite is proposed as a promising biosensor for uric acid for human health protection.
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