期刊
ACS SENSORS
卷 5, 期 4, 页码 936-942出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.9b02041
关键词
micromotor-based biosensing; active carrier; self-propelling particle; Janus particle; dielectrophoresis; ICEP
资金
- ISF [1938/16]
- Russell Berrie Nanotechnology Institute
- Micro-Nano Fabrication Unit
Previous micromotor-based biosensing studies used to tunctionalize the surface of the micromotor with specific molecular probes for binding of target analyte, thus limiting the use of the micromotor for the specific target. In contrast, here, we introduce a novel approach of using a nonfunctionalized micromotor as a generic cargo carrier being able to perform label-free and dynamic loading, transport, and release of functionalized beads. Hence, such an approach enables one to use the same micromotor system for sensing of varying targets via different commercially available functionalized beads, demonstrating the use of micromotors as a practical and versatile means for biosensing. We have also introduced a simplified microfluidic design that can be used for immunosensing or DNA binding tests without necessity for complicated fluid handling (buffer exchange, washing, etc. steps. We expect this approach to open up new realizations of simplified and generic biosensing platforms.
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