期刊
BIOTECHNOLOGY ADVANCES
卷 33, 期 2, 页码 277-287出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.02.004
关键词
Nanoparticles; BBB; Protein engineering; Recombinant proteins; Artificial viruses; Drug delivery; Gene therapy
资金
- Fundacio Marato TV3, Catalunya, Spain [TV32011-110533]
- Comision Sectorial de Investigacion Cientifica de la Universidad de la Republica (CSIC-UDELAR), Uruguay
- Agenda Nacional de Investigation e Innovacion (ANII), Uruguay
- FOCEM (MERCOSUR Structural Convergence Fund) [COF 03/11]
- FIS [PI12/00327]
- Fundacio Marato TV3 [TV32013-133930, TV32013-132031]
- MINECO [BIO2013-41019-P]
- Centro de Investigacion Biomedica en Red (CIBER) de Bioingenieria, Biomateriales y Nanomedicina
- European Regional Development Fund
- China Scholarship Council [2011630065]
- ISCIII [FI09/00150]
The increasing incidence of diseases affecting the central nervous system (CNS) demands the urgent development of efficient drugs. While many of these medicines are already available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose physical and biological limitations to their diffusion to reach target tissues. Therefore, efforts are needed not only to address drug development but specially to design suitable vehicles for delivery into the CNS through systemic administration. In the context of the functional and structural versatility of proteins, recent advances in their biological fabrication and a better comprehension of the physiology of the CNS offer a plethora of opportunities for the construction and tailoring of plain nanoconjugates and of more complex nanosized vehicles able to cross these barriers. We revise here how the engineering of functional proteins offers drug delivery tools for specific CNS diseases and more transversally, how proteins can be engineered into smart nanoparticles or 'artificial viruses' to afford therapeutic requirements through alternative administration routes. (C) 2015 Elsevier Inc. All rights reserved.
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