期刊
CANCER RESEARCH
卷 76, 期 1, 页码 4-6出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-15-3024
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资金
- NCI NIH HHS [P30 CA168524, R01 CA087728, R01 CA134981] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA087728, R01CA134981, P30CA168524] Funding Source: NIH RePORTER
Heterogeneity is commonplace in all cancer types and at several levels-intrinsic (genetic), epigenetic, positional, and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance. These properties have profound implications regarding the understanding of tumor behavior and how therapies are (or should be) administered. This brief commentary highlights the insightful review of Gloria Heppner and how it has influenced cancer research even three decades after it was published. (C) 2016 AACR.
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