期刊
FRONTIERS IN ENDOCRINOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.00012
关键词
cortisol; grouper; masculinization; protogynous; sex change
资金
- National Natural Science Foundation of China [31972769, 31902346, 31802274]
- Guangdong Provincial Natural Science Foundation [2018A030313890, 2018B030311026]
- Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams [2019KJ143]
- GDAS Special Project of Science and Technology Development [2019GDASYL-0103065]
- Science and Technology Planning Project of Huizhou [20170214023102296]
- Special Fund of State Key Laboratory of Developmental Biology of Freshwater [2018KF001]
- Guangdong South China Sea Key Laboratory of Aquaculture for Aquatic Economic Animals [KFKT2019ZD07]
In this study, we injected cortisol into the protogynous orange-spotted grouper (Epinephelus coioides) to investigate the role of this hormone in sex change. Following injection, we evaluated gonadal changes, serum levels of steroid hormones, and sex-related gene expression during the processes of cortisol-induced sex change and cortisol withdrawal in the orange-spotted grouper. Cortisol treatment caused the degeneration of oocytes and induced sex change in a dose-dependent manner. Over the long-term, we observed a significant increase in serum 11-ketotestosterone (11-KT) levels in all cortisol-treated groups, although levels of 17 beta-estradiol did not change significantly. Consistent with the elevation of serum 11-KT levels, the expression of genes related to testicular development was also significantly up-regulated in the cortisol-treated groups. Based on our results, we propose that cortisol may trigger masculinization by inducing the synthesis of 11-KT and by directly activating the expression of sex-related genes. Furthermore, we found that cortisol-induced sex change was not permanent and could be reversed after the withdrawal of cortisol treatment.
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