期刊
CELL SYSTEMS
卷 10, 期 2, 页码 125-132出版社
CELL PRESS
DOI: 10.1016/j.cels.2020.01.004
关键词
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资金
- NIH [R35GM124732]
- Pew Biomedical Scholars Program
- Searle Scholars Program
- Sloan Research Fellowship
- Smith Family Award for Excellence in Biomedical Research
- European Molecular Biology Organization Long-Term fellowship [ALTF 143-2018]
- National Science Foundation Graduate Research Fellowship
- NIH PreDoctoral training grant [T32 GM007287]
How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation.
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