期刊
SCIENCE BULLETIN
卷 65, 期 11, 页码 951-957出版社
ELSEVIER
DOI: 10.1016/j.scib.2019.12.006
关键词
Cathepsin C; Receptor activator of nuclear factor-kappa B; ligand; Periapical periodontitis; Tartrate resistant acid phosphatase
资金
- Open Research Fund Program of State Key Laboratory of Oral Disease, Sichuan Univeristy, China [SKLOD2019OF06]
Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed; this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-kappa B ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r = 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
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