期刊
REDOX BIOLOGY
卷 28, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.redox.2019.101326
关键词
Aquaporins; Peroxiporins; Hydrogen peroxide; Membrane permeability; Endoplasmic reticulum; Redox homeostasis
资金
- Associazione Italiana Ricerca sul Cancro [IG 2016-18824]
- Fondazione Cariplo [2015-0591]
- Telethon [GGP15059, GGP11139B]
- University of Ferrara
- Italian Ministry of Health [GR-2016-02364602]
- Italian Association for Cancer Research (AIRC) [IG-18624]
Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with 'peroxiporin' activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2. Unlike other peroxiporins, AQP11 is localized in the endoplasmic reticulum (ER), accumulating partly in mitochondrial-associated ER membranes (MAM). Its downregulation severely perturbs the flux of H2O2 through the ER, but not through the mitochondrial or plasma membranes. These properties make AQP11 a potential regulator of ER redox homeostasis and signaling.
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