期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.03065
关键词
ILCs; decidua; t-SNE; pregnancy; transcription factors; cytokines
类别
资金
- NIH Ruth L Kirschstein National Research Award [T32-HD041921]
- NIH TEAM-Science [R25 GM083252]
- UW SciMed GRS Fellowship
- NIH NLM Computation and Informatics in Biology and Medicine training grant [T15-LM007359]
- University of Wisconsin Carbone Cancer Center Support Grant [P30 CA014520]
- Wisconsin Partnership Program
- NIH NIAID [U19AI104317]
- NIH NCI [R01CA204320, R01CA219154-01]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development [K12HD000849-28]
- March of Dimes Basil O'Connor Award [5-FY18-541]
- Burroughs Wellcome Fund
- March of Dimes
- American Society for Reproductive Medicine, as part of the Reproductive Scientist Development Program
- Burroughs Wellcome Fund Preterm Birth Initiative [1019835]
- NIH [1S100OD018202-01, 1S10RR025483-01]
A successful pregnancy requires many physiological adaptations from the mother, including the establishment of tolerance toward the semiallogeneic fetus. Innate lymphoid cells (ILCs) have arisen as important players in immune regulation and tissue homeostasis at mucosal and barrier surfaces. Dimensionality reduction and transcriptomic analysis revealed the presence of two novel CD56(Bright) decidual ILCs that express low T-bet and divergent Eomes levels. Transcriptional correlation with recently identified first trimester decidual dNKs suggests that these novel decidual ILCs might be present throughout pregnancy. Functional testing with permutation analysis revealed production of multiple factors by individual cells, with a preference for IFN gamma and VEGF. Overall, our data suggests continuity of a unique decidual innate lymphocytes across pregnancy with a polyfunctional functional profile conducive for pregnancy
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