期刊
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
卷 20, 期 5, 页码 728-735出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530320666200213111452
关键词
n-3 fatty acids; microalgae; antioxidant; lipid peroxidation; diabetes; adipose tissue
资金
- Universidad Autonoma del Estado de Mexico [UAEM 4507/2018/CI]
- State of Mexico, Mexico
Background: Type 2 Diabetes Mellitus (T2DM) is considered a chronic noncommunicable disease in which oxidative stress is expected as a result of hyperglycaemia. One of the most recent approaches is the study of microalgae fatty acids and their possible antioxidant effect. Objective: This study aimed to analyse the effect of supplementation with n-3 fatty acids extracted from microalgae on the total antioxidant capacity (TAC) and lipid peroxidation of adipose tissue and plasma from diabetic (db/db) and healthy (CD1) mice. Methods: Mice were supplemented with lyophilized n-3 fatty acids extracted from microalgae or added to the diet, from week 8 to 16. TAC assay and Thiobarbituric Acid Reactive Substances assay (TBARS) were performed on adipose tissue and plasma samples. Results: The supplementation of lyophilized n-3 fatty acids from microalgae increased the total antioxidant capacity in adipose tissue of diabetic mice (615.67 mu M Trolox equivalents vs 405.02 mu M Trolox equivalents from control mice, p<0.01) and in the plasma of healthy mice (1132.97 +/- 85.75 mu M Trolox equivalents vs 930.64 +/- 32 mu M Trolox equivalents from modified diet mice, p<0.01). There was no significant effect on lipid peroxidation on both strains. Conclusion: The use of n-3 fatty acids extracted from microalgae could be a useful strategy to improve total antioxidant capacity in T2DM.
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