期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 11, 期 1, 页码 86-102出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-019-00700-8
关键词
Atmospheric plasma; Dexamethasone; Implant; Drug delivery; Apoptosis; Osteogenesis; Inflammation; Osteoblast; Macrophage; Otorhinolaryngology; Head and neck surgery
资金
- Shanghai Pujiang Program [19PJ1408800]
Implant-based local drug delivery using atmospheric pressure plasma technology creates a novel metallic implant with sustainable drug release and multiple biological benefits, making it a potent tool for future implant-based therapy.
Implant-based local drug delivery is a unique surgical therapy with many clinical advantages. Atmospheric pressure plasma is a novel non-thermal surface biotechnology that has only recently been applied in enhancing a surgical implant. We are the first to use this technology to successfully create a dexamethasone-delivery metallic implant. Irrespective of the loaded medication, the surface of this novel implant possesses advantageous material features including homogeneity, hydrophilicity, and optimal roughness. UV-vis spectroscopy revealed much more sustainable drug release compared to the implants produced using simple drug attachment. In addition, our drug-releasing implant was found to have multiple biological benefits. As proven by the ELISA data, this multi-layer drug complex provides differential regulation on the cell apoptosis, as well as pro-osteogenic and anti-inflammatory effects on the peri-implant tissue. Furthermore, using the pathway-specific PCR array, our study discovered 28 and 26 upregulated and downregulated genes during osteogenesis and inflammation on our newly fabricated drug-delivery implant, respectively. The medication-induced change in molecular profile serves as a promising clue for designing future implant-based therapy. Collectively, we present atmospheric pressure plasma as a potent tool for creating a surgical implant-based drug-delivery system, which renders multiple therapeutic potentials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据